- Histopathologic findings of necrotizing lymphadenitis.
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Young Ran Shim, Hae Joo Nam
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Yeungnam Univ J Med. 1993;10(2):485-492. Published online December 31, 1993
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DOI: https://doi.org/10.12701/yujm.1993.10.2.485
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- Necrotizing lymphadenitis was first recognised as a self-limiting lymphadenitis by Japanese workers in 1972. It is a distinct clinicopathologic entity, but can be mistaken as malignant lymphoma. We have studied clinicopathologic features in 15 cases of necrotizing lymphadenitis. This disease occurs predominantly in young adult. Male-female ratio is 2 : 1. The commonest presentation is lateral cervical lymphadenopathy. Pain, tenderness, and fever can be seen. Biopsy of the lymph nodes from all patients demonstrates the characteristic histologic features : multifocal, relatively circumscribed nodules in the cortex and/or paracortex, consisting of a mixture of activated large lymphoid cells, histiocytes and Small lymphocytes. Numerous karyorrhetic debris are present. Neutrophils and plasma cells are strikingly absent.
- Histopathologic consideration of hepatocellular carcinoma.
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Hae Joo Nam, Dong Suk Kim, Won Hee Choi, Tae Sook Lee
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Yeungnam Univ J Med. 1992;9(2):351-358. Published online December 31, 1992
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DOI: https://doi.org/10.12701/yujm.1992.9.2.351
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- Hepatocellular carcinoma represents approximately 90% of the primary liver cancers. Recently, its incidence tends to be increased. Thirsty seven cases from 1986 to 1991 diagnosed as hepatocellular carcinoma by resection were analyzed to know their histopathologic feature and related clinical findings. The average age at the time of resection was 53.1 years, with frequent occurrence in third and fourth decades. Microscopically, the trabecular type was the most frequent growth pattern (35.1%) and classic hepatocyte-like cell type was the most frequent cell type (75.7%). The tumors are mainly moderately differentiated and frequently associated with liver cirrhosis. In comparison of cytological differentiation with liver cirrhosis, there was a tendency for well-differentiated tumors to arise in cirrhotic livers more often than poorly differentiated tumors, and the tendency was statistically significant. But differentiation and tumor size did not show significant correlation. Also statistically significant correlations were not observed between the level of alpha-fetoprotein and tumor size, and between the level of alpha-fetoprotein and differentiation.
- Effect of phenobarbital pretreatment on the hepatotoxicity of carbon tetrachloride in rat.
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Young Soo Byun, Hae Joo Nam, Mi Jin Kim, Dong Suk Kim, Won Hee Choi, Tae Sook Lee
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Yeungnam Univ J Med. 1992;9(1):137-148. Published online June 30, 1992
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DOI: https://doi.org/10.12701/yujm.1992.9.1.137
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- The purpose of this study was to evaluate the influence of phenobarbital (PB) on hepatotoxic effect of carbon tetrachloride (CCI4) which induces centrilobular necrosis in liver. Rats were injected intraperitoneally CCI4 dissolved in olive oil by a dose of 0.4 mg/kg. For change related to PB pretreatment, rats were injected CCI₄ 0.4mg/kg after PB pretreatment. The liver samples were taken in 6, 12, 24, 48, 72 and 120 hours after CCI₄ and/ or PB injection. Extracted liver tissue was examined with light and electron microscopes. The results were summarized as follows: 1. Light microscopic findings: In CCI₄ group, centrilobular necrosis developed from 6 hours after injection, was the most severe in 48 hours, and recovered after 72 hours. In addition to necrosis, fatty change and pale cell change were accompanied. In PB-CCI4 group, necrosis occurred from 6 hours after CCI₄ injection and continued to 72 hours, and the degree of necrosis was more severe than that of CCI₄ group and pale cell change was decreased. 2. Electron microscopic findings: In CCI4 group, the early principal change was clumping and vesicular dilatation of endoplasmic reticulum. In PB-CCI₄ group, the degenerative change of endoplasmic reticulum was aggravated and the mitochondria also revealed severe degenerative change. According to the results, it was revealed that CCI₄ hepatotoxicity primarily began with the damage of endoplasmic reticulum, then damage of other cell organelles and cell necrosis followed, and these cytotoxic effects were aggravated by PB pretreatment.
- Effects of carbon tetrachloride on structures in hepatocytes following DMN induced hepatotoxicity.
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Young Chun Kang, Hae Joo Nam, Dong Suk Kim, Won Hee Choi, Tae Sook Lee
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Yeungnam Univ J Med. 1991;8(2):84-94. Published online December 31, 1991
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DOI: https://doi.org/10.12701/yujm.1991.8.2.84
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- The purpose of this study was to evaluate the influence of high dose carbon tetrachloride (CCI4) on the hepatotoxic effect of dimethylnitrosamine (DMN) which induces acute hemorrhagic necrosis in liver. Rats were injected intraperitoneally DMN dissolved in physiologic saline by a dose of 40 mg/kg. For changes related to CCI⁴ pretreatment, rats were injected intraperitoneally CCI⁴ dissolved in olive oil by a dose of 0.4 mg/kg, and then injected DMN. The livers were extracted from the rats 3, 6, 12, 24, 48, 72, and 120 hours after CCI⁴ and/ or DMN injection. Liver tissues were examined with light and electron microscopes. The results were summarized as follows; Light microscopic findings: Severe centrilobular hemorrhagic necrosis developed from 12 hours after injection of DMN and continued to 120 hours. On injection of DMN after CCI4 pretreatment, Massive necrosis occurred early. But active regenerative changes were produced in 24 hours. In 120 hours, the liver recovered in almost normal appearance. The degree of necrosis in pretreated group was similar to that in DMN injection only, and the time of recovery was faster in pretreated group. Electron microscopic findings: The early change was mainly disorganization of RER in DMN injection, and clumping and vesicular dilatation of ER in injection of CCI4. In pretreatment group, the early change was similar in appearance with CCI4 group, but severer in degree. According to the results, it was revealed that acute toxic effect of DMN was recovered more rapidly in pretreatment group. Thus it was suggested that CCI4 had protective effect in DMN hepatotoxicity.
- Histopathological study of gastric adenoma.
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Dong Sug Kim, Hae Joo Nam, Won Hee Choi, Tae Sook Lee, Moon Kwan Chung
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Yeungnam Univ J Med. 1991;8(2):76-83. Published online December 31, 1991
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DOI: https://doi.org/10.12701/yujm.1991.8.2.76
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- A total of 53 gastric adenomas from endoscopically biopsied gastric mucosa were examined histopathologically. The average age at the time of endoscopic biopsy was 59 years, and gastric adenomas were found to be more frequent in the aged, particularly above the age of 50. The majority of adenomas occurred at the antrum. Concerning the shape of the adenomas, Yamada type II was more frequent (55%). All adenomas were accompanied by varying degree of intestinal metaplasia, and this findings suggest that gastric adenoma develops from intestinal metaplasia. In adenomas with severe atypia (grade III), endocrine cells (argyrophil and argentaffin cells) were markedly decreased or absent. Gastric adenocarcinomas coexistent with adenoma were seen in 5 (9.4%) out of 53 cases, and were more frequent in male than female patients (sex ratio, 4:1) and the average age was 61.4 years. It is suggested that there is a necessity of thorough follow-up study for definitive correlation between gastric adenoma and adenocarcinoma.
- Metastatic tumors in supraclavicular lymph node: pathological analysis of 125 cases.
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Dong Sug Kim, Hae Joo Nam, Won Hee Choi, Tae Sook Lee
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Yeungnam Univ J Med. 1991;8(2):70-75. Published online December 31, 1991
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DOI: https://doi.org/10.12701/yujm.1991.8.2.70
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- Supraclavicular lymph nodes are unique in that they can attract metastases from almost anywhere in the body and most common sites of metastasis from an unknown primary source. 125 cases which had been diagnosed as metastatic supraclavicular lymph node during the period between May 1983 and August 1991, were analyzed pathologically, and following distinctive characteristics could be outlined: 1) The most frequent sites of metastasis from primary lesions are lung (43%), stomach (23%), lymphoreticular (6%), biliary (5%), esophagus (2%), and pancreas (2%). 2) Histologic examination of metastatic supraclavicular lymph node revealed adenocarcinoma (57%), squamous cell carcinoma (12%), undifferentiated carcinoma (9%), small cell carcinoma (7%), malignant lymphoma (6%), malignant melanoma (1%) and undetermined carcinoma (8%). 3) In cases that histologic types were squamous cell carcinoma, undifferentiated carcinoma, small cell carcinoma and undetermined carcinoma, the most frequent primary site was lung.
- Nucleolar organizer regions in glioma.
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Hae Joo Nam, Dong Suk Kim, Won Hee Choi, Tae Sook Lee
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Yeungnam Univ J Med. 1991;8(2):63-69. Published online December 31, 1991
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DOI: https://doi.org/10.12701/yujm.1991.8.2.63
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- Nucleolar organizer regions (NOR) are loops of ribosomal DNA (rDNA) which are transcribed by RNA polymerase I. They produce ultimately ribosome and protein. Thus they are believed to reflect nuclear activity. We applied silver colloid staining technique to human glioma to examine relationship between the mean number of Ag-NOR and histopathological grading. The mean number of Ag-NOR (±S. E of the mean) were 1.17±0.07 in normal brain, 1.53±0.25 in astrocytoma, 2.37±0.71 in malignant astrocytoma. And 2.88±0.41 in glioblastoma multiforme. And there was a statistically significant difference among these. The results show that Ag-NOR technique is a rather simple and rapid method and will become a helpful tool for estimation of the proliferative potential of glioma.
- The Comparison of Histopathology of Cats Received Conventional Mechanical Ventilation and High Frequency Oscillation Ventilation.
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Kwan Ho Lee, Young Jo Kim, Jae Chun Chung, Hyun Woo Lee, Hae Joo Nam, Tae Sook Lee
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Yeungnam Univ J Med. 1989;6(2):39-46. Published online December 31, 1989
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DOI: https://doi.org/10.12701/yujm.1989.6.2.39
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- The tracheobronchial histopathologic findings in 7 healthy cats used with high frequency oscillation ventilation (HFOV) were compared with those in 6 cats used with conventional mechanical ventilation (CMV). 4-point, 9-variable scoring system was used to evaluate the injury in the trachea, right & left main bronchi and parenchyma. The following results were obtained; 1) The tracheobronchial tree received HFOV had no significant damage compared with CMV (P>0.05). 2) Intraepithelial mucus loss and emphysema were slightly more prominent in CMV groups. As above results; the tracheobronchial histopathologic difference was not prominent between CMV and HFOV groups received with relatively short period, however, the cellular of function and barotrauma may be more prominent in CMV groups. From now on, as causes of tracheobronchial injury in HFV, interaction between humidification and mechanical trauma considers further study.
- A Case of Conjoined Twins.
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Mi Hwa Kang, Son Moon Shin, Jin Gon Jun, Mi Jin Kim, Hae Joo Nam, Sung Rim Kim, Jong Wook Kim
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Yeungnam Univ J Med. 1988;5(2):255-261. Published online December 31, 1988
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DOI: https://doi.org/10.12701/yujm.1988.5.2.255
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- Conjoined twinning is a rare congenital malformation, accounting for 1% monozygotic twins. Conjoined twins result if twining is initiated after the embryonic disc and rudimentary amniotic sac have been formed and if division of the embryonic disc is incomplete. Recently we experienced a case of conjoined twins, dicephalus dipus dibrachius, who had died at 3 hours of life, and performed autopsy. Autopsy revealed a total duplication of the heads, spines up to sacrum, small bowels, thymus and lungs. Two hearts existed within a common pericardium.
- Three Cases of Primary Adenosquamous Carcinoma of Stomach.
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Joon Hyuk Choi, Mi Jin Kim, Hae Joo Nam, Won Hee Choi, Tae Sook Lee
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Yeungnam Univ J Med. 1988;5(2):189-193. Published online December 31, 1988
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DOI: https://doi.org/10.12701/yujm.1988.5.2.189
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- Adenosquamous carcinoma of stomach is a mixed glandular-epidermoid tumor where both components are neoplastic. Its incidence is extremely rare. The five theories on the origin of squamous components are 1) island of ectopic squamous epithelium in the gastric mucosa, 2) squamous metaplasia of gastric epithelium, 3) squamous differentiation in a preexisting adenocarcinoma, 4) endothelial cell differentiated toward squamous elements, and 5) totipotential undifferentiated cells of the gastric mucosa. We experienced three cases of adenosquamous carcinoma. Case 1 was a 71-year-old female patient; an ulcerative lesion was present in the pylorus, measuring 5 cm in diameter. Case 2 was a 57-year-old male patient; an ulcerative lesion is present in the pylorus, measuring 6 cm in diameter. Case 3 was a 58-year-old female patient; an ulcerative lesion was present in the body and fundus, measuring 10 cm in diameter. Microscopic examination revealed a mixed malignant squamous and adenomatous component.
- Four Cases of Primary Malignant Melanoma of the Nasal Cavity.
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Mi Jin Kim, Hae Joo Nam, Won Hee Choi, Tae Sook Lee
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Yeungnam Univ J Med. 1988;5(1):135-139. Published online June 30, 1988
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DOI: https://doi.org/10.12701/yujm.1988.5.1.135
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- The primary malignant melanoma of the nasal cavity and paranasal sinuses is extremely rare and accounts for only between 0.6 and 2.5% of the total number of malignant melanoma at all sites. In the nose, the left side is involved in 60% of cases and the most frequent site is the septum followed by the inferior and middle turbinates. In the sinuses, the maxillary sinus is the site of origin 80% of cases, followed by ethmoid sinus. The tumors are sessile or polypoid, with variable color such as pink, white, brown or blank. Of all tumors, 10-30% are amelanotic, requiring special stains for melanin. When primary site of melanoma is mucosal origin, treatment of primary lesion is often hampered by anatomic restrictions and large size, which results from the delayed diagnosis caused by their location. We report 4 cases of primary malignant melanoma of nasal cavity with review of literature.
- Histopathological Study of Carcinoma of the Colorectum in the Taegu Area.
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Hae Joo Nam, Won Hee Choi, Tae Sook Lee, Suk Jae Hong
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Yeungnam Univ J Med. 1986;3(1):33-39. Published online December 31, 1986
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DOI: https://doi.org/10.12701/yujm.1986.3.1.33
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- A clinical and statistical study was done for 123 patients with histologically proven colorectal malignant tumor from 1983 to 1986 at the department of anatomical pathology. Yeungnam University Hospital. The results were as follows: 1. Ratio between male and female was 1.6:1 and incidence was most prevalent in 7th decades comprising 29.3%. 2. Location of tumor was the most frequent in rectum (65%). 3. Frequent symptoms and signs in case of right colon were pain, abdominal mass and bowel habit change. In left colon, they were pain, bowel habit change and bloody stool or melena. In rectum, they were bloody stool or melena, bowel habit change and pain. 4. Duration of symptom was 1 to 3 months (33.3%). 5. The most frequent histological type was adenocarcinoma (82.9%). 6. According to Duke's classification, 32.9% of the tumor were stage C2. 7. Operative procedures were Mile's operation (47.0%), right hemicolectomy (19.8%), and lower anterior resection (11.7%). 8. Polyps were the most frequent associated disease. 9. The most common complication was wound infection (11.1%).
- A Case Combined Germ Cell Tumor in Testis.
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Hae Joo Nam, Won Hee Choi, Tae Sook Lee, Jun Gyu Suh, Kyung Chul Lee
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Yeungnam Univ J Med. 1985;2(1):293-297. Published online December 31, 1985
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DOI: https://doi.org/10.12701/yujm.1985.2.1.293
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- Primary germ cell tumor of the testis is rare, which occupies 1 to 2% of all reported malignant male neoplasms. Combined primary germ cell tumor of the testis composed of embryonal carcinoma and seminoma is more rare tumor. The authors experienced a case of 50-year old male who presented with painless enlargement of right testicle. He has had radical orchiectomy and diagnosed by pathologically as combined germ cell tumor of testis. The testicle is measuring 180 gm in weight and 9×6×5 cm in dimension, and almostly replaced by tumor mass. Grossly the tumor is rubbery solid smooth tumor mass, with variegated cut surface with geographically outlined diffuse necrotic area. Histologically the tumor is composed of two components of tumor, which are solid growth pattern of large round to polyhedral cells with clear or granular cytoplasm and distinct cell border, and anastomosing glandular and papillary arrangement of anaplastic epithelial cells. The former corresponds to seminoma, and the latter to embryonal carcinoma. Each tumor lobule is separated by abundant fibrous stroma.
- Prostatic Urethral Polyp Causing Lower Urinary Tract Obstruction: Report of a Case.
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Dong Heon Lee, Jun Kyu Suh, Young Soo Kim, Tong Choon Park, Hae Joo Nam, Won Hee Choi, Tae Sook Lee, Kyung Chul Lee
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Yeungnam Univ J Med. 1985;2(1):249-252. Published online December 31, 1985
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DOI: https://doi.org/10.12701/yujm.1985.2.1.249
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- Polyps of the male urethra are relatively uncommon lesions, They usually arise from the prostatic urethra mostly verumontanum or just lateral to the verumontanum. Posterior urethral polyp often presents with hematuria, hemospermia and sometimes lower urinary tract obstruction. We recently experienced a pedunculated prostatic urethral polyp in a 63-year-old man who complained of gross total hematuria and difficult micturition for several years. On rectal examination the prostate was slightly enlarged with normal consistency. Excretory urogram showed a round filling defect in the right side of the bladder neck measuring about 2×2 cm in size. Cystourethroscopy revealed trabeculation of the vesical wall, mild bilateral prostatic hypertrophy and a round cystic mass with a long stalk arising from the prostatic floor 1cm. Proximal to the verumontanum which caused ball-valve obstruction in the bladder neck. This pedunculated polypoid mass was then resected at its base with resectoscope and was removed transurethrally using Lowsley's grasping forceps. The specimen was proved as fibrous polyp histologically.
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